Though you can also increase the resistance of the '42 driver tube's grid to increase bass response, there is a chance of the grid being driven positive, with subsequent grid current being drawn, which can be a bad situation. Still, I have seen resistances as high as 1 meg on these tubes with favorable audio results. It's better to increase the plate resistance of the 1st AF tube.
Increasing the grid and plate resistances will also tend to decrease the upper register, especially when the plate resistance of the 1st AF tube is increased, but you probably won't notice this much. This is due to the time constant being a bit too sloppy for high frequency response. You might also notice a slight increase in the upper middle register, though, again, probably not. Negative feedback, if you use it, will take care of this.
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